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Association of Migraine Disorders Research Grant
The purpose of this RFP is to support novel and transformative evidence-based research into migraine-related disorders. A preference will be given to basic science projects. Specifically the purpose of this RFP is: 1. To understand the pathophysiology of the neural malfunction that is called migraine disease 2. To prove or disprove a common pathophysiology among the multiple symptoms and syndromes that claim a relationship to migraine 3. To improve our understanding of the natural history of migraine disease at various stages of life, such as the differences between episodic and persistent migraine symptoms 4...
Source: ScanGrants feed - October 8, 2014 Category: Research Authors: Association of Migraine Disorders Source Type: funding

Migraine trait symptoms in migraine with and without aura
Conclusions: The observed SNS seem to belong to a physiologic spectrum of multisensory phenomena. Some of these phenomena were significantly accentuated in patients with migraine and may therefore be termed migraine trait symptoms. However, these results will have to be confirmed in a prospective study with face-to-face interviews.
Source: Neurology - April 21, 2014 Category: Neurology Authors: Jurgens, T. P., Schulte, L. H., May, A. Tags: Migraine, All Clinical Neurology, Hallucinations ARTICLE Source Type: research

Comment: Outcomes of migraine therapy with IV dihydroergotamine
IV dihydroergotamine (DHE) is a widely used treatment for status migrainosus or refractory chronic migraine, but there are few published studies on outcomes of this therapy.1 The report by Eller et al.2 adds to our current understanding of the effects of DHE, with a thorough description of their experience at an academic inpatient headache unit. Although the observations are retrospective, this kind of careful documentation and systematic reporting of patient experience can be enormously valuable in characterizing "real world" patient management issues. One such issue is the transient worsening of headache associated with ...
Source: Neurology - February 29, 2016 Category: Neurology Authors: Charles, A. Tags: Migraine, Class IV ARTICLE Source Type: research

Non-invasive Brain Stimulation in Pediatric Migraine: A Perspective From Evidence in Adult Migraine
Conclusions The Cochrane reviews do not provide clear conclusions regarding the effectiveness of TMS and tDCS against adult chronic pain, although small benefits appear to have been observed. However, the authors point out many biases and important heterogeneities of these studies (30). At the moment, it is not possible to establish useful guidelines on the use of TMS and tDCS in the treatment of pediatric migraine and, in general, for pediatric pain treatment. However, adult studies as well as preliminary pediatric reports show that the application of these techniques is safe, with few side effects, potentially low cost...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Migraine History and Associated Comorbidities in High School Athletes (N3.001)
Conclusions:Student athletes with pre-existing migraines are statistically more likely to have other comorbidities. Athletes with migraine only did not perform more poorly on cognitive testing, but they did report more baseline preseason symptoms. Those with migraine and other comorbidities demonstrated poorer cognitive performance and symptoms increased with additional comorbidities. This study highlights the importance of assessing recovery from symptoms post-injury in light of possible higher baseline symptoms in those with comorbidities.Disclosure: Dr. Wojtowicz has nothing to disclose. Dr. Iverson has nothing to discl...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Wojtowicz, M., Iverson, G., Silverberg, N., Gerrard, P., Atkins, J. E., Zafonte, R., Berkner, P., Seifert, T. Tags: Neuroscience in the Clinic: Cutting Edge Concussion Data from the NCAA-DoD Grand Alliance Source Type: research

Evaluation of Occipital Nerve Blocks for Acute Pain Relief of Migraines.
Abstract Migraines are a debilitating neurological disease affecting as many as 1 of 6 adults in the United States. Occipital nerve block, consisting of a local anesthetic and/or corticosteroid, has shown to be an effective treatment for the management of migraines. Occipital nerve block has been reported to reduce migraine pain scores, frequency, and duration. We aimed to evaluate the impact of occipital nerve block for acute pain relief in patients with migraines. This was a single-center retrospective observational study conducted at a 1162-bed academic medical center in Gainesville, Florida. Included patients ...
Source: The Journal of Clinical Pharmacology - October 7, 2019 Category: Drugs & Pharmacology Authors: Ebied AM, Nguyen DT, Dang T Tags: J Clin Pharmacol Source Type: research

Majority of Patients Endorsing Post Traumatic Migraine Headaches Features Are Females (P3.332)
Conclusions: Patients who present to the outpatient neurology concussion clinic and continue to endorse symptoms beyond 30 days are very likely to endorse severe and frequent headaches that can be classified into migraines. Those who endorse migraine headaches are highly likely to be females. A neurology concussion clinic should be equipped to handle patients with more severe symptoms who are more likely to endorse academic and emotional difficulties. Migraine management expertise would also be needed.Disclosure: Dr. Hawash has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Hawash, K. Tags: Neuro Trauma and Sports Neurology Source Type: research

5E.1. Associations between the Gut Microbiome and Migraines in 7-18-Year-Old Children: The American Gut Cohort Analysis
10% children suffer from migraine which result in more school absences and lower academic performance. Recent literature proposed that the gut microbiome may impact migraines through increased intestinal epithelial permeability and inflammation. This quantitative study examined the associations between the gut microbiome and migraines among a cohort of children aged 7-18 years from the American Gut Project (AGP). Findings can help understand biological mechanisms of migraines so that personalized interventions can be designed towards migraine control.
Source: Pain Management Nursing - March 31, 2019 Category: Nursing Authors: Jinbing Bai Source Type: research

IJERPH, Vol. 20, Pages 5499: Perceived Stress and Impact on Role Functioning in University Students with Migraine-Like Headaches during COVID-19
Conclusions: During COVID-19, more students answered that their migraine-like headaches had lower impacts on their role functioning, thus suggesting that the students were having less severe migraines. A trend was seen for student’s stress levels, indicating a decrease from 2019 to 2021. Furthermore, our results showed that the impact of headaches and stress levels slightly declined throughout the pandemic.
Source: International Journal of Environmental Research and Public Health - April 13, 2023 Category: Environmental Health Authors: Nauris Tamulevicius Ritika Save Nishita Gandhi Sean Lubiak Siddhi Sharma Claudia X. Aguado Loi Khyam Paneru Mary P. Martinasek Tags: Article Source Type: research

New Trends in Migraine Pharmacology: Targeting Calcitonin Gene –Related Peptide (CGRP) With Monoclonal Antibodies
Conclusion Migraine is a disabling and debilitating neurovascular painful condition representing more than 90% of cases of recurrent headache and toward which the tendency can be inherited (MacGregor, 2017). Divalproex sodium, sodium valproate, topiramate, metoprolol, propranolol, and timolol have proven strong, level A, evidence for migraine prevention (American Academy of Neurology and American Headache Society, 2015). However, all the classic oral preventative treatments including tricyclic antidepressants, beta blockers, 5-HT2 antagonists ergots and anti-epileptic drugs were not developed for migraine and provide 50% ...
Source: Frontiers in Pharmacology - April 8, 2019 Category: Drugs & Pharmacology Source Type: research

Potential association between recurrent facial nerve palsy and migraines.
CONCLUSION: The results raise the possibility of an association between recurrent facial nerve palsy and migraines. Prospective studies in patients with even fewer episodes of facial nerve palsy could shed more light on this association. PMID: 32940194 [PubMed - as supplied by publisher]
Source: Journal of Laryngology and Otology - September 18, 2020 Category: ENT & OMF Tags: J Laryngol Otol Source Type: research

Prospective cohort study of routine exercise and headache outcomes among adults with episodic migraine.
CONCLUSION: In patients with EM, those who reported moderate-vigorous exercise at least three times per week had fewer headache days per month, though not statistically significant. This association was significantly stronger in those who used prophylactic medication for migraines. Exercise appeared not to be associated with the severity or duration of headaches. Routine moderate-vigorous exercise may be an important adjunctive strategy for improving headache burden in patients eligible for migraine prophylaxis. PMID: 33349935 [PubMed - as supplied by publisher]
Source: Headache - December 21, 2020 Category: Neurology Authors: Hagan KK, Li W, Mostofsky E, Bertisch SM, Vgontzas A, Buettner C, Mittleman MA Tags: Headache Source Type: research

Prevalence of migraine headaches and their impact on the academic performance of Sudanese medical students using ID ‐Migraine test as a screening tool: A cross‐sectional study
ConclusionsWith prevalence similar to adults, primary care physicians should be aware of the probability of migraine headaches in university students in order to maintain a successful school performance.
Source: Brain and Behavior - April 22, 2022 Category: Neurology Authors: Moaid Mohamed Osman Ali, Khabab Abbasher Hussien Mohamed Ahmed, Mohammed Eltahier Abdalla Omer Tags: ORIGINAL RESEARCH Source Type: research

Introduction to Progressive Muscle Relaxation Therapy for Migraine in the Emergency Department: A Pilot Feasibility Study (P2.168)
Conclusions:Migraine patients presenting to the ED have severe and frequent migraines which make them candidates for preventive behavioral treatments. PMR is a behavioral technique which can be introduced in the ED setting. Follow-up studies should examine whether patients will continue to use these behavioral techniques at home.Study Supported by: Dr. Mia Minen is a recipient of the American Academy of Neurology-American Brain Foundation Practice Research Training Fellowship.Disclosure: Dr. Minen has nothing to disclose. Dr. Boubour has nothing to disclose. Dr. Powers has nothing to disclose. Dr. Grudzen has nothing to di...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Minen, M., Boubour, A., Powers, S., Grudzen, C., Lipton, R. Tags: Headache: Clinical Trials and Therapeutics Source Type: research

Multicenter prevalence of opioid medication use as abortive therapy in the emergency department treatment of migraine headaches
This study describes treatment practices in regards to migraines in the ED. It characterizes the prevalence of opioid orders during visits in three different settings, an academic medical center, a non-academic urban ED, and a community ED.Fourteen months of consecutive migraine visits were identified. All medications ordered were separated into first-line and rescue medications.
Source: The American Journal of Emergency Medicine - June 16, 2017 Category: Emergency Medicine Authors: Neil Young, Daniel Silverman, Heather Bradford, Jeffrey Finkelstein Source Type: research